McAfee loses high-profile researcher and CTO (Reuters)

BOSTON (Reuters) ? Two senior technology executives have resigned from McAfee Inc, the anti-virus software maker that Intel Corp bought in February, according to a company spokeswoman.

Worldwide Chief Technology Officer George Kurtz, who helped lead the company's product strategy, will leave at the end of this month, the spokeswoman said.

Kurtz could not be reached for comment.

Vice President Dmitri Alperovitch, a highly regarded threat researcher whose work at the company help give it a reputation for conducting cutting-edge research on hacking, quietly left last month, without the company issuing any announcement.

Alperovitch led a research team that produced several high-profile studies on suspected Chinese-government backed hackers during his tenure at McAfee.

Those studies included a landmark January 2010 report in which Alperovitch coined the term "Operation Aurora" to describe attacks suspected by Chinese hackers on Google Inc and several dozen other companies. His team identified the malware used in those attacks, which exploited previously unknown flows in Microsoft Corp's Internet Explorer browser.

In August his team uncovered "Operation Shady RAT," the biggest series of cyber attacks disclosed to date, which involved the infiltration of the networks of 72 organizations including the United Nations, governments and companies around the world.

Alperovitch, who has been doing consulting since he left the company, declined to comment on the reason for his resignation.

Company spokeswoman Heather Edell said the company is currently looking for replacements for the two executives.

(Reporting by Jim Finkle, editing by Bernard Orr)

Source: http://us.rd.yahoo.com/dailynews/rss/security/*http%3A//news.yahoo.com/s/nm/20111018/tc_nm/us_mcafee_departures

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Clinton in Libya to offer new aid package (AP)

TRIPOLI, Libya ? U.S. Secretary of State Hillary Rodham Clinton is offering new assistance to Libya's provisional leadership on an unannounced visit to the Libyan capital.

Clinton arrived in Tripoli on Tuesday from Malta and is meeting with senior members of Libya's National Transitional Council. U.S. officials say she will present a new package of aid, including more support for Libyan efforts to find and destroy thousands of shoulder-fired missiles that many fear could fall into the hands of terrorists.

She also is to announce medical assistance for former rebels wounded in fighting with Moammar Gadhafi's (MOO'-ah-mar gah-DAH'-fee) loyalists.

Officials say Clinton will also raise the case of the Lockerbie bomber.

Clinton is the most senior Obama administration official to visit Libya since the uprising against Gadhafi began in February.

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/ap/20111018/ap_on_re_af/af_us_clinton_libya

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Faulty molecular switch can cause infertility or miscarriage

ScienceDaily (Oct. 16, 2011) ? Scientists have discovered an enzyme that acts as a 'fertility switch', in a study published in Nature Medicine on October 16. High levels of the protein are associated with infertility, while low levels make a woman more likely to have a miscarriage, the research has shown.

The findings have implications for the treatment of infertility and recurrent miscarriage and could also lead to new contraceptives. Around one in six women have difficulty getting pregnant and one in 100 women trying to conceive have recurrent miscarriages, defined as the loss of three or more consecutive pregnancies.

Researchers from Imperial College London looked at tissue samples from the womb lining, donated by 106 women who were being treated at Imperial College Healthcare NHS Trust either for unexplained infertility or for recurrent pregnancy loss.

The women with unexplained infertility had been trying to get pregnant for two years or more and the most common reasons for infertility had been ruled out. The researchers discovered that the womb lining in these women had high levels of the enzyme SGK1. Conversely, the women suffering from recurrent pregnancy loss had low levels of SGK1.

The team found further evidence of SGK1's importance in experiments using mouse models. Levels of SGK1 in the womb lining decline during the fertile window in mice. When the researchers implanted extra copies of the SGK1 gene into the womb lining, the mice were unable to get pregnant, suggesting that a fall in SGK1 levels is essential for making the uterus receptive to embryos.

The research at the Institute of Reproductive and Developmental Biology (IRDB) at Imperial College London was led by Professor Jan Brosens, who is now based at the University of Warwick. "Our experiments on mice suggest that a temporary loss of SGK1 during the fertile window is essential for pregnancy, but human tissue samples show that they remain high in some women who have trouble getting pregnant," he said. "I can envisage that in the future, we might treat the womb lining by flushing it with drugs that block SGK1 before women undergo IVF. Another potential application is that increasing SGK1 levels might be used as a new method of contraception."

Any infertility treatment that blocks SGK1 would have to have a short-lived effect, as low levels of the protein after conception seem to be linked to miscarriage. When the researchers blocked the gene that codes for SGK1 in mice, the mice had no problem getting pregnant. However, they had smaller litters and showed signs of bleeding in the uterus, suggesting that lack of SGK1 made miscarriage more likely.

After an embryo is implanted, the lining of the uterus develops into a specialised structure called the decidua, and this process can be made to occur when cells from the uterus are cultured in the lab. Cultured cells from women who had had three or more consecutive miscarriages had significantly lower levels of SGK1 compared to cells from controls.

Blocking the SGK1 gene, both in pregnant mice and in human cell cultures, impaired the cells' ability to protect themselves against oxidative stress, a condition in which there is an excess of reactive chemicals inside cells.

"We found that low levels of SGK1 make the womb lining vulnerable to cellular stress, which might explain why low SGK1 was more common in women who have had recurrent miscarriage," said Madhuri Salker, the study's first author, Institute of Reproductive and Developmental Biology (IRDB) at Imperial College London. "In the future, we might take biopsies of the womb lining to identify abnormalities that might give them a higher risk of pregnancy complications, so that we can start treating them before they get pregnant."

The research was funded by the Consortium for Industrial Collaboration in Contraceptive Research, the Genesis Research Trust, and the Imperial Comprehensive Biomedical Research Centre, established by a grant from the National Institute of Health Research.

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Story Source:

The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Imperial College London, via EurekAlert!, a service of AAAS.

Journal Reference:

  1. Madhuri S Salker, Mark Christian, Jennifer H Steel, Jaya Nautiyal, Stuart Lavery, Geoffrey Trew, Zoe Webster, Marwa Al-Sabbagh, Goverdhan Puchchakayala, Michael F?ller, Christian Landles, Andrew M Sharkey, Siobhan Quenby, John D Aplin, Lesley Regan, Florian Lang, Jan J Brosens. Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nature Medicine, 2011; DOI: 10.1038/nm.2498

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/10/111016132043.htm

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Instant view: Jobless claims dip 1,000 last week (Reuters)

NEW YORK (Reuters) ? New claims for unemployment benefits edged down last week, according to a government report on Thursday that pointed to a modest improvement in the labor market at the start of the fourth quarter.

The U.S. trade deficit narrowed marginally in August, but the trade gap with China widened to a record high, the Commerce Department said on Thursday.

COMMENTS:

STEVEN WOOD, CHIEF ECONOMIST, INSIGHT ECONOMICS, DANVILLE, CALIFORNIA

"Initial claims slipped slightly in the latest week and remained just above the 400,000 level where it has been for the 25th time in the last 26 weeks. After averaging 459,000 per week in 2010, new jobless claims have averaged 415,000 this year, a clear indication that the pace of layoffs has slowed. However, layoffs remain relatively high and there has been little incremental improvement over the past 6 months. The labor market remains relatively stagnant."

STEPHEN STANLEY, CHIEF ECONOMIST, PIERPONT SECURITIES, STAMFORD, CONNECTICUT

TRADE GAP: "This is consistent with anecdotal evidence that there is weakness in consumer goods imports. Retailers are very cautious. They are stocking lightly before the holidays. I would expect this could happen again in September.

"Consumers are doing okay. Last year, retailers actually undershot and they ran out of stocks during the holidays. This could happen again this year.

"With the number pretty close to expectations, it would not have a lot of impact on third-quarter GDP, which is running in the 2.0-2.5 percent area."

DAVID SLOAN, ECONOMIST, IFR ECONOMICS, A UNIT OF THOMSON REUTERS

"The August trade deficit of $45.6 bln was close to a $45.8 bln consensus, and unchanged from July, but with July's deficit revised up from $44.8 bln the deficit net of revisions can be seen as a little higher than expected. Exports and imports were also both virtually unchanged from July, though the deficit widened slightly in real terms after a sharp July improvement. Net exports still look likely to make a positive contribution to Q3 GDP but the trade report should keep expectations for that release with a 2 handle, improved from the first half of the year but still not strong enough to reduce unemployment."

"The August deficit with China of $29.0 bln was the highest on record, and up from $27.0 bln in July, but only a modest deterioration from $28.2 bln a year ago. More notable is a rise in the deficit with Japan to $6.7 bln from $5.2 bln in July and $5.8 bln a year ago, a sign that supply restraints are fading as an issue here with imports from Japan the highest since June 2008. The subdued tone of overall imports is now therefore a reflection on the state of US demand."

JEFFREY GREENBERG, ECONOMIST, NOMURA SECURITIES, NEW YORK

"The trend is going in the right direction. Despite relatively week payrolls over the past few months, it's been an issue of firms not adding to their payrolls rather than firms starting to cut because of economic uncertainty. That means that firms are in the position to eventually start adding.

"We see it as a relatively bright spot in a mixed bag of data and so far we've seen a lot of relatively strong hard data in the past few weeks despite sentiment and general soft data telling us there's been a lack of confidence. But as was made clear by the minutes to the FOMC yesterday and Plosser's comments, even if we get good data out of the U.S. it doesn't mean that much because the focus is really on Europe.

"We get some good data, but minutes later it seems like people realize the U.S. is vulnerable to influences from the outside.

"Trade data are outdated. And no surprises there. Treasuries seem to be pretty much unfazed."

YELENA SHULYATYEVA, U.S. ECONOMIST, BNP PARIBAS, NEW YORK

"This is a slight dip in claims, but this is too early to say things are improving. The four-week moving average is still above 400,000. What we are seeing is that as the economic outlook weakens, employers tend to slow their hirings, and claims don't capture that."

SUBODH KUMAR, CHIEF INVESTMENT STRATEGIST, SUBODH KUMAR & ASSOCIATES IN TORONTO

"Claims seem to be sticky around the 400,000 area, which suggests that the economy remains weak. There's no week-to-week change of any substance. The issue for equities is going to be revenue growth, which looks weak. On the other side, the European financial situation isn't settled, which will keep the dollar buoyant."

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/nm/20111013/bs_nm/us_usa_economy_jobs_instant

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Serbia soccer coach Petrovic resigns

Vladimir Petrovic

updated 10:08 a.m. ET Oct. 14, 2011

BELGRADE, Serbia - Serbia's national team coach Vladimir Petrovic resigned Friday after the failure to qualify for the European Championship.

Serbia lost 1-0 to Slovenia on Tuesday, missing out on a place in the playoffs for Euro 2012. Estonia took the playoff spot, while Italy topped Group C.

Petrovic said he stepped down after an agreement with Serbia's soccer federation.

Petrovic took over the national team after two Euro qualification matches last year when former coach Radomir Antic was fired.

Petrovic, a former Arsenal and Red Star Belgrade midfielder, previously coached China's national team. He was dismissed in 2008 after China was eliminated from qualifying for the 2010 World Cup.

Petrovic was hired by Red Star in 2009, but was fired after less than a year in charge.

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Rooney's career passing him by

??When Wayne Rooney set alight the Euros at 18, no one could have predicted that the brilliant but flawed gem of England would become such a disappointment and liability.

Source: http://nbcsports.msnbc.com/id/44903114/ns/sports-soccer/

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Cicadas, or how I Am Such A Scientist, or a demonstration of good editing

Originally published on May 16th, 2011 at my old blog.

Charles Q. Choi runs a bi-weekly series on the Guest Blog over at Scientific American ? Too Hard for Science? In these posts, he asks scientists about experiments that cannot be or should not be done, for a variety of reasons, though it would be fun and informative it such experiments could get done.

For one of his posts, he interviewed me. What I came up with, inspired by the emergence of periodic cicadas in my neighborhood, was a traditional circadian experiment applied to a much longer cycle of 13 or 17 years.

Fortunately for me, Charles is a good editor. He took my long rant and turned it into a really nice blog post. Read his elegant version here ? Too Hard for Science? Bora Zivkovic?Centuries to Solve the Secrets of Cicadas.

Now compare that to the original text I sent him, posted right here:

The scientist: Bora Zivkovic, Blog Editor at Scientific American and a chronobiologist.

The idea: Everything in living organisms cycles. Some processes repeat in miliseconds, others in seconds, minutes or hours, yet others in days, months or years. Biological cycles that are most studied and best understood by science are those that repeat approximately once a day ? circadian rhythms.

One of the reasons why daily rhythms are best understood is that pioneers of the field came up with a metaphor of the ?biological clock? which, in turn, prompted them to adapt oscillator theory (the stuff you learned in school about the pendulum) from physics to biology.

And while the clock metaphor sometimes breaks down, it has been a surprisingly useful and powerful idea in this line of research. Circadian researchers came up with all sorts of experimental protocols to study how daily rhythms get entrained (synchronized) to the environmental cycles (usually light-dark cycles of day and night), and how organisms use their internal clocks to measure other relevant environmental parameters, especially the changes in daylength (photoperiod) ? information they use to precisely measure the time of year and thus migrate, molt or mate during an appropriate season.

These kinds of experiments ? for example building Phase-Response Curves to a variety of environmental cues, or a variety of tests for photoperiodism (night-break protocol, skeleton photoperiods, resonance cycles, T-cycles, Nanda-Hamner protocol etc.) ? take a long time to perform.

Each data point requires several weeks: measuring period and phase of the oscillation before and after the pulse (or a series of pulses) of an environmental cue in order to see how application of that cue at a particular phase of the cycle affects the biological rhythm (or the outcome of measuring daylength, e.g., reproductive response). It requires many data points, gathered from many individual organisms.

And all along the organisms need to be kept in constant conditions: not even the slightest fluctuations in light (usually constant darkness), temperature, air pressure, etc. are allowed.

It is not surprising that these kinds of experiments, though sometimes applied to shorter cycles (e.g., miliseconds-long brain cycles), are rarely applied to biological rhythms that are longer than a day, e.g., rhythms that evolved as adaptations to tidal, lunar and annual environmental cycles. It would take longer to do than a usual, five-year period of a grant, and some experiments may last an entire researcher?s career. Which is one of the reasons we know so little about these biological rhythms.

~~~~~~

Living out in the country, in the South, just outside Chapel Hill, NC, every day I open the door I hear the deafening and ominous-sounding noise (often described as ?horror movie soundtrack) coming from the woods surrounding the neighborhood. The cicadas have emerged! The 13-year periodic cicadas, that is. Brood XIX.

I was not paying attention ahead of time, so I did not know they were slated to appear this year in my neck of the woods. One morning last week, I saw a cicada on the back porch and noticed red eyes! A rule of thumb that is easy to remember: green eyes = annual cicadas, red eyes = periodic cicadas. I got excited! I was waiting for this all my life!

Fortunately, once they emerge, cicadas are out for a few weeks, so my busy travel schedule did not prevent me from going to find them (just follow the sound) to take a few pictures and short videos.

There are three species of periodic cicadas that emerge every 17 years ? Magicicada septendecim, Magicicada cassini and Magicicada septendecula. Each of these species has a ?sister species? that emerges every 13 years: M.tredecim, M. tredecassini and M.tredecula. A newer species split produced another 13-year species: Magicicada neotredecim. The species differ in morphology and color, while the 13 and 17-year pairs of sister species are essentially indistinguishable from each other. M.tredecim and M.neotredecim, since they appear at the same time and place, differ in the pitch of their songs: M.neotredecim sings a higher tone.

So, how do they count to 13 or 17?

While under ground, they undergo metamorphosis four times and thus go through five larval instars. The 13 and 17-year cicadas only differ in the duration of the fifth instar. They emerge simultaneously, live as adults for a few weeks, climb up the trees, sing, mate, lay eggs and die.

When the eggs hatch, the newly emerged larvae fall from the trees to the ground, dig themselves deeper down, latch onto the tree roots to feed on the sap, and wait another 13 or 17 years to emerge again.

There are a number of hypotheses (and speculations) why periodic cicadas emerge every 13 or 17 years, including some that home in on the fact that these two numbers are prime numbers (pdf).

Perhaps that is a way to fool predators which cannot evolve the same periodicity (but predators are there anyway, and will gladly gorge on these defenseless insects when they appear, whenever that is, even though it may not be so good for them). Perhaps this is a speciation mechanism, lowering the risk of hybridization between recently split sister species?

Or perhaps that is all just crude adaptationist thinking and the strangeness of the prime-number cycles is in the eye of the beholder ? the humans! After all, if an insect shows up every year, it is not very exciting. Numerous species of annual cicadas do that every year and it seems to be a perfectly adaptive strategy for them. But if an insect, especially one that is so large, noisy and numerous, shows up very rarely, this is an event that will get your attention.

Perhaps our fascination with them is due to their geographic distribution. Annual cicadas may also have very long developmental times, but all of their broods are in one place, thus the insects show up every year. In periodic cicadas, different broods appear in different parts of the country, which makes their appearance rare and unusual in each geographic spot.

In any case, I am more interested in the precision of their timing than in potential adaptive explanations for it. How do they get to be so exact? Is this just a by-product of their developmental biology? Is 13 or 17 years just a simple addition of the duration of five larval stages?

Or should we consider this cycle to be an output of a ?clock? (or ?calendar?) of sorts? Or perhaps a result of interactions between two or more biological timepieces, similarly to photoperiodism? In which case, we should use the experimental protocols from circadian research and apply them to cicada cycles.

Finally, it is possible that a ling developmental cycle is driven by one timing mechanism, but the synchronization of emergence in the last year is driven by another, perhaps some kind of clock that may be sensitive to sound made by other insects of the same species as they start digging their way up to the surface.
The problem: In order to apply the standard experiments (like construction of a Phase-Response Curve, or T-cycles), we need to bring the cicadas into the lab. And that is really difficult to do. Husbandry has been a big problem for research on these insect, which is why almost all of it was done out in the field.

When kept in the lab, the only way to feed them is to provide them with the trees so they can drink the sap from the roots. This makes it impossible to keep them in constant conditions ? trees require light and will have their own rhythms that the cicadas can potentially pick up, as timing cues, from the sap. So, the first thing we need to do is figure out a way to feed them artificially, without reliance on living trees for food.

Also, we do not know which environmental cues are relevant. Is it light cycle? Photoperiod? Or something cycling in the tree-sap? Or temperature cycles? What are the roles of developmental hormones like Juvenile Hormone or Ecdysone? We would have to test all of them simultaneously, hoping that at least one of them turns out to be the correct one.

Second, more obvious problem, is time. These experiments would last hundreds of years, perhaps thousands! Some experiments rely on outcomes of previous experiments for the proper design. Who would do them? What funding agency would finance them? Why would anyone start such experiments while knowing full well that the results would not be known within one?s lifetime? Isn?t this too tantalizing for a scientist?s curiosity?

The solution? One obvious solution is to figure out ways to get to the same answers in shorter time-frames. Perhaps by sequencing the genome and figuring out what each gene does (perhaps by looking at equivalents in other species, like fruitflies, or inserting them into Drosophila and observing their effects), hoping to find out the way timing is regulated. This will probably not answer all our questions, but may be good enough.

Another way is to set aside space and funding for such experiments and place them into an unusual administrative framework ? a longitudinal study guided by an organization, not a single researcher getting a grant to do this in his or her lab. This way the work will probably get done, and the papers will get published somewhere around 2835 A.D.

~~~~

See? How long and complex my text is? Now go back to the post by Charles to see again how nicely he edited the story.

Source: http://rss.sciam.com/click.phdo?i=35c4d0064d9162b932e5b2e9dd1f8a16

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Love & harmonious relationships are not just for the dream world ...

When I look at the people in my life, beyond my children ? it is those I have sat in meditation with that I have such deep connections.

There is something ?silent? about our relationship that allows a ?Knowing? of each other that cannot be fooled by the occasional displays of ego.

I ?feel? them whether they are physically present in my life or not, aware of their ?cries of help? ? constantly aware of the love I have for them that cannot be tainted. For there is something sacred that we share that could not ever have been explored or felt with words.

It was sitting in each other?s silence that allowed each of us to be ?seen?, it was in this silence we felt something stir in our hearts. It was silence that ?lit? this love.

?

In tantra, it is suggested that lovers meditate together.? Now, I do not feel this brings to the relationship simply conscious & connected sex, I feel it ?allows? so much more than that ?

Meditating with a lover, simply drinking in each other?s presence may bring many harmonious benefits to a relationship. ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ??

There is a feeling of sacredness, for you have seen the other in all their innocence. You have seen, felt & shared your soul.? This brings safety & strength in being vulnerable, open ? a warm softness to the relationship.? Boundaries ? ?any need to protect begins to fall away.

There is a new expression to communication, for no words are required for there to be an understanding of the other.? So much more can be given, tasted & felt in the beauty of each other?s silence. This bond creates a knowing of each other?s needs for touch, love, space ? & how to ?meet? them.

In that ?Knowing? of the other, honesty to communication with words arises, for we know that the other has ?space? in their heart to listen & receive ? & that although words can be spoken that cause hurt, we trust in the love shared & know this hurt ?belongs to ?self?, that the other is lovingly giving us an?opportunity?for the?healing for our wounds. ?They are words that will assist us to no longer ?act? out of ego, patterns & the past with each other but from NOW & LOVE.

Being present together brings new, fresh eyes to the relationship for it is a relationship of NOW. ?We are ?seen in the moment? which is an?incredible?gift of love.

Meditating together forms deep bonds of trust & love as you open more & more to each other & unfold & grow together. The deeper the love is felt & shared, the more freedom is felt individually for there is a release of all that is not ?real? ?. An expansion of two minds, two bodies, a unity of two souls. ?I believe sharing this silence cam build strong foundations to any relationship, for no matter what is going on externally, a sense of harmony, unity & peace can be felt ?humming? softly beneath the dramas ? waiting to carry the both of you into a deeper understanding of self & each other.

Now, I also feel we do not have to sit cross legged on the floor together, or be in Yab Yum ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Just being silent while holding each other, breathing each other in & out in a circular breath or simply breathing together ? falling into each other, til there is no distance between you.

Allowing more conscious moments of touch ??caressing?with no?intention or agenda?for sex but just the simple pleasure of touching the other?s skin, smelling their smell.

Spending more silent time together, rather than feeling uncomfortable in the silence, desperately grabbing for words to say or the TV remote control ?. Just feeling, Being with the other.

Nature lives in perfect balance, flowing, moving, expanding, weaving in & out of all the cycles of the moon, the stars, the seasons ? all growing together, not apart.? This is our natural state of being.

Harmony, pleasure, connection, deep eternal &?unconditional?love, bliss, freedom ?

We sing about these things as if they belong only for our dreamtime.

We write poetry & love stories ??

But we can only dream these dreams, sing these songs, write these words because it lives as a potential within the heart of all us.

Source: http://www.inspiritess.com/2011/10/love-harmonious-relationships-are-not-just-for-the-dream-world/

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